Review: Viral infections and mechanisms of thrombosis and bleeding
Identifieur interne : 000C01 ( Main/Exploration ); précédent : 000C00; suivant : 000C02Review: Viral infections and mechanisms of thrombosis and bleeding
Auteurs : M. Goeijenbier [Pays-Bas] ; M. Van Wissen [Pays-Bas] ; C. Van De Weg [Pays-Bas] ; E. Jong [Pays-Bas] ; V. E. A. Gerdes [Pays-Bas] ; J. C. M. Meijers [Pays-Bas] ; D. P. M. Brandjes [Pays-Bas] ; E. C. M. Van Gorp [Pays-Bas]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2012-10.
English descriptors
- Teeft :
- Activator, Active antiretroviral therapy, Acute cytomegalovirus infection, American college, Anticardiolipin antibodies, Anticoagulant, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid syndrome, Antiretroviral, Antiretroviral therapy, Antithrombin, Asherson, Autoantibody, Better understanding, Blood coagulation, Brandjes, Bray, Brin, Brin deposition, Brin strands, Brinogen, Brinolysis, Brinolysis inhibitor, Cascade, Case report, Cervera, Chest physicians, Chronic hepatitis, Clin, Clin microbiol, Clinical picture, Clinical presentation, Coagulation, Coagulation abnormalities, Coagulation activation, Coagulation cascade, Coagulation disorders, Coagulation markers, Coagulation proteins, Coagulation system, Cofactor, Complication, Cytokine, Cytomegalovirus, Cytomegalovirus infection, Deep venous thrombosis, Dengue, Dengue hemorrhagic fever, Dengue shock syndrome, Dengue virus, Dengue virus infection, Dengue virus infections, Disease severity, Ebola, Ebola hemorrhagic fever, Ebola virus, Endothelial, Endothelial cell activation, Endothelial cells, Endothelium, Fibrinolysis, Gastroenterol, Geisbert, Gharavi, Glycoprotein, Goeijenbier, Gorp, Groot, Haemost, Hajjar, Hantavirus, Hantaviruses, Hemorrhagic, Hemorrhagic complications, Hemorrhagic fever, Hemorrhagic fever viruses, Hemorrhagic viruses, Hemostasis, Hemostatic, Hemostatic parameters, Hensley, Heparin, Heparin cofactor, Hepatitis, Herpes, Herpes viruses, Idiopathic thrombocytopenic purpura, Infection, Inhibitor, Intravascular, Intravascular coagulation, Jahrling, Keller, Klein, Kurugol, Laine, Lassa, Lassa fever, Lassa fever patients, Levi, Lijfering, Liver disease, Lupus anticoagulant, Mairuhu, Parvovirus, Passos, Pathogen, Pathogenesis, Pathogenic hantaviruses, Pathol, Pathophysiological mechanisms, Pathway, Pediatr, Petechial rash, Plasminogen, Plasminogen activator, Plasminogen activator inhibitor type, Platelet, Platelet activation, Platelet aggregation, Platelet count, Platelet surface, Portal vein, Prieto, Primary hemostasis, Proc natl acad, Procoagulant, Procoagulant state, Prothrombin, Prothrombin fragment, Prothrombotic, Pulmonary embolism, Pulmonary hemorrhage, Purpura, Renal, Renal syndrome, Respiratory syndrome, Respiratory tract infections, Respiratory viruses, Rhesus monkeys, Sars, Schouten, Seasonal variations, Simplex, Soluble thrombomodulin, Sosothikul, Squizzato, Supportive care, Syndrome, Therapeutic strategies, Thromb, Thromb haemost, Thrombin, Thrombin generation, Thrombocytopenia, Thrombocytopenic, Thrombomodulin, Thrombosis, Thrombotic, Thrombotic complications, Thrombotic microangiopathy, Thrombotic thrombocytopenic purpura, Tissue factor, Tissue factor pathway, Tissue factor pathway inhibitor, Varicella, Vascular, Vascular complications, Venous, Venous thrombosis, Viii, Violi, Viral, Viral hemorrhagic fevers, Viral hepatitis, Viral infection, Viral infections, Viral pathogens, Virol, Virus, Virus infection, Wang, Willebrand, Willebrand factor, Zhang.
Abstract
Viral infections are associated with coagulation disorders. All aspects of the coagulation cascade, primary hemostasis, coagulation, and fibrinolysis, can be affected. As a consequence, thrombosis and disseminated intravascular coagulation, hemorrhage, or both, may occur. Investigation of coagulation disorders as a consequence of different viral infections have not been performed uniformly. Common pathways are therefore not fully elucidated. In many severe viral infections there is no treatment other than supportive measures. A better understanding of the pathophysiology behind the association of viral infections and coagulation disorders is crucial for developing therapeutic strategies. This is of special importance in case of severe complications, such as those seen in hemorrhagic viral infections, the incidence of which is increasing worldwide. To date, only a few promising targets have been discovered, meaning the implementation in a clinical context is still hampered. This review discusses non‐hemorrhagic and hemorrhagic viruses for which sufficient data on the association with hemostasis and related clinical features is available. This will enable clinicians to interpret research data and place them into a perspective. J. Med. Virol. 84:1680–1696, 2012. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jmv.23354
Affiliations:
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Goeijenbier</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, University of Rotterdam</wicri:regionArea><wicri:noRegion>University of Rotterdam</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Correspondence address: Department of Virology, Erasmus Medical Centre, University of Rotterdam, dr Molenwaterplein 50, Rotterdam 3015CJ</wicri:regionArea><wicri:noRegion>Rotterdam 3015CJ</wicri:noRegion></affiliation></author><author><name sortKey="Van Wissen, M" sort="Van Wissen, M" uniqKey="Van Wissen M" first="M." last="Van Wissen">M. Van Wissen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Slotervaart Hospital, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van De Weg, C" sort="Van De Weg, C" uniqKey="Van De Weg C" first="C." last="Van De Weg">C. Van De Weg</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, University of Rotterdam</wicri:regionArea><wicri:noRegion>University of Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Jong, E" sort="Jong, E" uniqKey="Jong E" first="E." last="Jong">E. Jong</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Slotervaart Hospital, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Gerdes, V E A" sort="Gerdes, V E A" uniqKey="Gerdes V" first="V. E. A." last="Gerdes">V. E. A. Gerdes</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Slotervaart Hospital, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, University of Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Meijers, J C M" sort="Meijers, J C M" uniqKey="Meijers J" first="J. C. M." last="Meijers">J. C. M. Meijers</name><affiliation wicri:level="4"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, University of Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Brandjes, D P M" sort="Brandjes, D P M" uniqKey="Brandjes D" first="D. P. M." last="Brandjes">D. P. M. Brandjes</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Slotervaart Hospital, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Gorp, E C M" sort="Van Gorp, E C M" uniqKey="Van Gorp E" first="E. C. M." last="Van Gorp">E. C. M. Van Gorp</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, University of Rotterdam</wicri:regionArea><wicri:noRegion>University of Rotterdam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">84</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1680">1680</biblScope><biblScope unit="page" to="1696">1696</biblScope><biblScope unit="page-count">17</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-10">2012-10</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activator</term><term>Active antiretroviral therapy</term><term>Acute cytomegalovirus infection</term><term>American college</term><term>Anticardiolipin antibodies</term><term>Anticoagulant</term><term>Antiphospholipid</term><term>Antiphospholipid antibodies</term><term>Antiphospholipid syndrome</term><term>Antiretroviral</term><term>Antiretroviral therapy</term><term>Antithrombin</term><term>Asherson</term><term>Autoantibody</term><term>Better understanding</term><term>Blood coagulation</term><term>Brandjes</term><term>Bray</term><term>Brin</term><term>Brin deposition</term><term>Brin strands</term><term>Brinogen</term><term>Brinolysis</term><term>Brinolysis inhibitor</term><term>Cascade</term><term>Case report</term><term>Cervera</term><term>Chest physicians</term><term>Chronic hepatitis</term><term>Clin</term><term>Clin microbiol</term><term>Clinical picture</term><term>Clinical presentation</term><term>Coagulation</term><term>Coagulation abnormalities</term><term>Coagulation activation</term><term>Coagulation cascade</term><term>Coagulation disorders</term><term>Coagulation markers</term><term>Coagulation proteins</term><term>Coagulation system</term><term>Cofactor</term><term>Complication</term><term>Cytokine</term><term>Cytomegalovirus</term><term>Cytomegalovirus infection</term><term>Deep venous thrombosis</term><term>Dengue</term><term>Dengue hemorrhagic fever</term><term>Dengue shock syndrome</term><term>Dengue virus</term><term>Dengue virus infection</term><term>Dengue virus infections</term><term>Disease severity</term><term>Ebola</term><term>Ebola hemorrhagic fever</term><term>Ebola virus</term><term>Endothelial</term><term>Endothelial cell activation</term><term>Endothelial cells</term><term>Endothelium</term><term>Fibrinolysis</term><term>Gastroenterol</term><term>Geisbert</term><term>Gharavi</term><term>Glycoprotein</term><term>Goeijenbier</term><term>Gorp</term><term>Groot</term><term>Haemost</term><term>Hajjar</term><term>Hantavirus</term><term>Hantaviruses</term><term>Hemorrhagic</term><term>Hemorrhagic complications</term><term>Hemorrhagic fever</term><term>Hemorrhagic fever viruses</term><term>Hemorrhagic viruses</term><term>Hemostasis</term><term>Hemostatic</term><term>Hemostatic parameters</term><term>Hensley</term><term>Heparin</term><term>Heparin cofactor</term><term>Hepatitis</term><term>Herpes</term><term>Herpes viruses</term><term>Idiopathic thrombocytopenic purpura</term><term>Infection</term><term>Inhibitor</term><term>Intravascular</term><term>Intravascular coagulation</term><term>Jahrling</term><term>Keller</term><term>Klein</term><term>Kurugol</term><term>Laine</term><term>Lassa</term><term>Lassa fever</term><term>Lassa fever patients</term><term>Levi</term><term>Lijfering</term><term>Liver disease</term><term>Lupus anticoagulant</term><term>Mairuhu</term><term>Parvovirus</term><term>Passos</term><term>Pathogen</term><term>Pathogenesis</term><term>Pathogenic hantaviruses</term><term>Pathol</term><term>Pathophysiological mechanisms</term><term>Pathway</term><term>Pediatr</term><term>Petechial rash</term><term>Plasminogen</term><term>Plasminogen activator</term><term>Plasminogen activator inhibitor type</term><term>Platelet</term><term>Platelet activation</term><term>Platelet aggregation</term><term>Platelet count</term><term>Platelet surface</term><term>Portal vein</term><term>Prieto</term><term>Primary hemostasis</term><term>Proc natl acad</term><term>Procoagulant</term><term>Procoagulant state</term><term>Prothrombin</term><term>Prothrombin fragment</term><term>Prothrombotic</term><term>Pulmonary embolism</term><term>Pulmonary hemorrhage</term><term>Purpura</term><term>Renal</term><term>Renal syndrome</term><term>Respiratory syndrome</term><term>Respiratory tract infections</term><term>Respiratory viruses</term><term>Rhesus monkeys</term><term>Sars</term><term>Schouten</term><term>Seasonal variations</term><term>Simplex</term><term>Soluble thrombomodulin</term><term>Sosothikul</term><term>Squizzato</term><term>Supportive care</term><term>Syndrome</term><term>Therapeutic strategies</term><term>Thromb</term><term>Thromb haemost</term><term>Thrombin</term><term>Thrombin generation</term><term>Thrombocytopenia</term><term>Thrombocytopenic</term><term>Thrombomodulin</term><term>Thrombosis</term><term>Thrombotic</term><term>Thrombotic complications</term><term>Thrombotic microangiopathy</term><term>Thrombotic thrombocytopenic purpura</term><term>Tissue factor</term><term>Tissue factor pathway</term><term>Tissue factor pathway inhibitor</term><term>Varicella</term><term>Vascular</term><term>Vascular complications</term><term>Venous</term><term>Venous thrombosis</term><term>Viii</term><term>Violi</term><term>Viral</term><term>Viral hemorrhagic fevers</term><term>Viral hepatitis</term><term>Viral infection</term><term>Viral infections</term><term>Viral pathogens</term><term>Virol</term><term>Virus</term><term>Virus infection</term><term>Wang</term><term>Willebrand</term><term>Willebrand factor</term><term>Zhang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infections are associated with coagulation disorders. All aspects of the coagulation cascade, primary hemostasis, coagulation, and fibrinolysis, can be affected. As a consequence, thrombosis and disseminated intravascular coagulation, hemorrhage, or both, may occur. Investigation of coagulation disorders as a consequence of different viral infections have not been performed uniformly. Common pathways are therefore not fully elucidated. In many severe viral infections there is no treatment other than supportive measures. A better understanding of the pathophysiology behind the association of viral infections and coagulation disorders is crucial for developing therapeutic strategies. This is of special importance in case of severe complications, such as those seen in hemorrhagic viral infections, the incidence of which is increasing worldwide. To date, only a few promising targets have been discovered, meaning the implementation in a clinical context is still hampered. This review discusses non‐hemorrhagic and hemorrhagic viruses for which sufficient data on the association with hemostasis and related clinical features is available. This will enable clinicians to interpret research data and place them into a perspective. J. Med. Virol. 84:1680–1696, 2012. © 2012 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Goeijenbier, M" sort="Goeijenbier, M" uniqKey="Goeijenbier M" first="M." last="Goeijenbier">M. Goeijenbier</name></noRegion><name sortKey="Brandjes, D P M" sort="Brandjes, D P M" uniqKey="Brandjes D" first="D. P. M." last="Brandjes">D. P. M. Brandjes</name><name sortKey="Gerdes, V E A" sort="Gerdes, V E A" uniqKey="Gerdes V" first="V. E. A." last="Gerdes">V. E. A. Gerdes</name><name sortKey="Gerdes, V E A" sort="Gerdes, V E A" uniqKey="Gerdes V" first="V. E. A." last="Gerdes">V. E. A. Gerdes</name><name sortKey="Goeijenbier, M" sort="Goeijenbier, M" uniqKey="Goeijenbier M" first="M." last="Goeijenbier">M. Goeijenbier</name><name sortKey="Goeijenbier, M" sort="Goeijenbier, M" uniqKey="Goeijenbier M" first="M." last="Goeijenbier">M. Goeijenbier</name><name sortKey="Jong, E" sort="Jong, E" uniqKey="Jong E" first="E." last="Jong">E. Jong</name><name sortKey="Meijers, J C M" sort="Meijers, J C M" uniqKey="Meijers J" first="J. C. M." last="Meijers">J. C. M. Meijers</name><name sortKey="Van De Weg, C" sort="Van De Weg, C" uniqKey="Van De Weg C" first="C." last="Van De Weg">C. Van De Weg</name><name sortKey="Van Gorp, E C M" sort="Van Gorp, E C M" uniqKey="Van Gorp E" first="E. C. M." last="Van Gorp">E. C. M. Van Gorp</name><name sortKey="Van Wissen, M" sort="Van Wissen, M" uniqKey="Van Wissen M" first="M." last="Van Wissen">M. 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